聯系電話:(前臺轉接撥0)

021-67179266(國佳)

021-54827631(國強)

生物合成工程實驗室
Biosynthetic Engineering Laboratory

生物合成工程實驗室致力于代謝工程、合成生物學和分子生理學研究,已建立了成熟的大腸桿菌、畢赤酵母和鏈霉菌的遺傳操作平臺。與生物過程工程研究相補充和支持,構建高效的細胞工廠,服務于工業生物技術、農業生物技術、醫藥生物技術和環境生物技術等多個生物技術領域。
Our research work focuses on metabolic engineering, synthetic biology and molecular physiology on the basis of the well-established platforms for genetic manipulation of E. coli, P. pastoris and Streptomyces ssp.. Combined with the bioprocess engineering, we are harnessing the synthetic power of biology to build microbial cell factories for industrial, agricultural, medical, and environmental applications.


研究成果
1.GAP promoter library for fine-tuning gene expression in Pichia pastoris. Applied and Environmental Microbiology. 2011, 77: 3600-3608.
2.Reliable high-throughput approach for screening of engineered constitutive promoters in the yeast Pichia pastoris. Letters in Applied Microbiology. 2011, 52: 634-641.
3.Toward improvement of erythromycin A production in an industrial Saccharopolyspora erythraea strain via facilitation of genetic manipulation with an artificial attB site for specific recombination. Applied and Environmental Microbiology. 2011, 77: 7508-7516.
4.Progress in the research of S-adenosyl-L-methionine production. Applied Microbiology and Biotechnology. 2013, 97: 41-49.
5.Impacts of high β-galactosidase expression on central metabolism of recombinant Pichia pastoris GS115 using glucose as sole carbon source via 13C metabolic flux analysis. Journal of Biotechnology. 2014, 187: 124-134.
專利
1.GAP啟動子文庫在調節S-腺苷甲硫氨酸代謝途徑中的應用. 專利號 ZL 201010621230.1
2.GAP啟動子文庫及其用途. 專利號 ZL 200910053198.9

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